protein
| interacting with GABRG2, NSF, GOSR1 and beta-tubulin |
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interacting with ULK1 |
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interaction partner of OSBPL7, GABARAPL2 regulates Golgi SNARE of 28kDa (GOSR1) function and stability, and plays a role in autophagosome biogenesis |
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ATG4B is required for processing GABARAPL2 for the latter to be conjugated to phosphatidylethanolamine on autophagosomal membranes, a key step in autophagosome biogenesis ( |
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GABARAPL2 targets Atg1/ULK1 to autophagosomes, where it may promote autophagosome maturation and/or fusion with vacuoles/lysosomes |
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ULK1 interacted most strongly with GABARAP and GABARAPL1, but it also interacted with GABARAPL2, MAP1LC3A, and MAP1LC3C |
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partners of CLN8 are VAPA, C14orf1/hERG28, STX8, GABARAPL2, BNIP3 and BNIP3L proteins and are associated with biologically relevant processes such as synthesis and transport of lipids, vesicular/membrane trafficking, autophagy/mitophagy and apoptosis |
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interaction between the human cytosolic family member GIMAP6 and GABARAPL2 |
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MCOLN3 and MCOLN3-loop specifically bind to GABARAPL2 and interaction facilitates the function of GABARAPL2 in autophagosome formation, but was not required for MCOLN3 trafficking to autophagosomes |
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MAP1LC3B, GABARAPL2 and GABARAP might play specific roles in different autophagic processes |
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GABARAP subfamily members, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are primary contributors to PINK1/Parkin mitophagy and starvation autophagy |
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FKBP8 is an GABARAPL1, GABARAPL2-interacting protein |
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ATG7 recognizes GABARAPL1, GARAPL2 through multiple steps, which would be necessary to induce a conformational change in ATG7 that is optimal for the activation reaction |