basic FUNCTION
| having perhaps a role in transcriptional regulation |
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acting as an histone demethylases specific for di- and trimethylated histone 3 lysine 4 (H3K4) |
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playing a potential role for in NR-mediated transcription |
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increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcription by CLOCK-ARNTL in a demethylase-independent manner |
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has a nonredundant role in circadian oscillator function |
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its lysine demethylase activity is dispensable for normal circadian rhythms in mammalian cells, its HDAC-inhibiting function appears to be necessary for proper oscillator function |
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KDM5A and KDM5B demethylases are tumor-suppressor network controlling cellular senescence |
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critical role of H3K4 demethylation by KDM5A in the transcriptional silencing of genes that are suppressed by RB family members in differentiated cells |
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is likely involved in the transformation of gonocytes into spermatogonial stem cells by transcriptional regulation of specific genes via H3K4 histone modification |
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retinoblastoma binding protein KDM5A removes methyl marks from lysine 4 of histone H3 (H3K4) |
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is a direct repressor of metabolic regulatory genes, thus explaining the compensatory role of KDM5A deletion in restoring mitochondrial function and differentiation |
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enzymatic activity of the KDM5 family required to be the linked JmjN-JmjC domain coupled with the immediate C-terminal helical zinc-binding domain, providing structural characterization of the linked JmjN-JmjC domain for the KDM5 family |