basic FUNCTION
| phosphorylation dependent ubiquination |
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substrate recognition subunit of SCF ubiquitin protein ligase complex |
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geranylgeranylated cellular protein required for hepatitis C virus RNA replication (PMID; |
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impairs cell proliferation by mediating cyclin D3 polyubiquitination and degradation |
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implicated as an indispensible regulator of mitosis that serves as a tumor suppressor ( |
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role for SCF (FBXL2) in regulating the fidelity of cellular division |
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ubiquitinates and destabilizes cyclin D2 protein leading to G(0) phase arrest and apoptosis in leukemic and B-lymphoblastoid cell lines |
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is a novel and dual regulator of APP metabolism through FBXL2-dependent ubiquitination of APP |