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FLASH GENE
Symbol PIK3R3 contributors: mct - updated : 05-12-2018
HGNC name phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
HGNC id 8981
Location 1p34.1      Physical location : 46.505.812 - 46.598.708
Synonym name
  • phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)
  • PI3-kinase p85 subunit gamma
  • PtdIns-3-kinase p85-gamma
  • Synonym symbol(s) p55, DKFZp686P05226, FLJ41892, p55-GAMMA, p55PIK
    DNA
    TYPE functioning gene
    STRUCTURE 92.57 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text transcripts 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 5194 - 461 highly in testis Suzuki, Dey (1998)
    - splicing 5693 - 461 highly in testis Dey (1998)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal YXXM motif, two SH2 domains, binding site
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine P55pik
    Homologene
    FAMILY
  • PI3K p85 subunit family
  • CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • interacting with the IGFIR and INSR and may be involved in PI 3-kinase activation by these receptors
  • 1-phosphatidylinositol-3-kinase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IGF1R or INSR
  • ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT1 and up-regulation of MIA3, thereby regulating endothelial cell functions directly relevant to atherosclerosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS