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FLASH GENE
Symbol TUSC2 contributors: mct - updated : 19-05-2012
HGNC name tumor suppressor candidate 2
HGNC id 17034
Location 3p21.31      Physical location : 50.362.340 - 50.365.668
Synonym name
  • lung cancer candidate
  • chromosome 3 open reading frame 11
  • PDGFA associated protein 2
  • Synonym symbol(s) LGCC, PAP, FUS1, C3orf11, PDAP2
    DNA
    TYPE functioning gene
    STRUCTURE 3.33 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1691 - 110 - -
    EXPRESSION
    Rna function mRNA transcripts could be detected in both normal lung and some lung cancer cell lines
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Respiratorylung    
    Urinarykidney    
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY FUS1 family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be functioning as a tumor suppressor, inhibiting colony formation, causing G1 arrest
  • ultimately inducing apoptosis
  • myristoylation is required for TUSC2-mediated tumor-suppressing activity
  • activates transcription of multiple genes with tumor suppressor properties and down-regulates pro-tumorigenic genes, thus supporting its role as a tumor suppressor
  • may act as a tumor suppressor in bone and soft-tissue sarcomas
  • potential role as a tumor suppressor in human lung cancer
  • critical role of the UTRs of TUSC2 transcripts in downregulation of TUSC2 transcription and translation in lung cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in mesothelioma
    tumoral     --low  
    detected in 82p100 of non-small cell lung carcinomaand 100p100 of small cell lung carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    TUSC2 UTRs can be used as potential therapeutic targets by developing small molecules and biological agents that can effectively block or interrupt the interaction of negative regulators with these cis-determinants in TUSC2 UTRs to re-activate TUSC2 expre
    ANIMAL & CELL MODELS
    Tusc2-deficient mice display a complex immuno-inflammatory phenotype with a predisposition to cancer