basic FUNCTION
| may be functioning as a tumor suppressor, inhibiting colony formation, causing G1 arrest |
|
ultimately inducing apoptosis |
|
myristoylation is required for TUSC2-mediated tumor-suppressing activity |
|
activates transcription of multiple genes with tumor suppressor properties and down-regulates pro-tumorigenic genes, thus supporting its role as a tumor suppressor |
|
may act as a tumor suppressor in bone and soft-tissue sarcomas |
|
potential role as a tumor suppressor in human lung cancer |
|
critical role of the UTRs of TUSC2 transcripts in downregulation of TUSC2 transcription and translation in lung cancer cells |