basic FUNCTION
| involved in endonucleolytic cleavage and polyadenylation of mRNA |
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pre-mRNA 3'-end-processing endonuclease |
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endonuclease and 5'-3' exonuclease activities in histone-pre-mRNA processing |
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responsible for the endonucleolytic cleavage that, during transcription, defines the 3& |
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900; end of nuclear-encoded mRNAs and the site of addition of the stable poly(A)-tail |
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important regulatory protein that represses the basal transcriptional activity of the HIV-1 LTR promoter |
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CPSF3 and CPSF2 act together in the process of maturation of eukaryotic pre-messenger RNAs, similar to other members of the MBL family, RNases Z and J, which function as homodimers |
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catalyzing the endonucleolytic cleavage |
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catalysing the 3prime-end cleavage of histone pre-mRNAs, requiring the interaction of two U7 snRNP-associated proteins, CASP8AP2 and LSM11 |
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can be recruited to histone pre-mRNA largely in a manner independent of CASP8AP2, possibly by a separate domain in LSM11 |
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both MBLAC1 and, as expected, CPSF3 depleted cells are impaired in efficiently entering/progressing in S-phase |
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promotes Replication-dependent (RD) histone pre-mRNA processing |