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FLASH GENE
Symbol IGSF5 contributors: mct/npt - updated : 03-07-2008
HGNC name immunoglobulin superfamily, member 5
HGNC id 5952
Location 21q22.2      Physical location : 41.117.333 - 41.174.021
Genatlas name
  • junctional adhesion molecule 4
    • Synonym name immunoglobulin superfamily 5 like
    Synonym symbol(s) GSF5, JAM4
    DNA
    TYPE functioning gene
    STRUCTURE 56.00 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2066 - 407 - Ota (2004)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta   
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell
    Reproductivegerm cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an intracellular Ig-like domain with potential N glycosylation site
  • a transmembrane segment
  • a cytoplasmic tail
  • two PDZ domains
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    basic FUNCTION
  • implicated in the regulation of paracellular permeability and the signalings of hepatocyte growth factor
  • implicated in the reorganization of cell junctions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAGI1
  • interacting with LNX1(directly binds the second PDZ domain of LNX1 through its carboxyl terminus)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS