protein
| substrate specificity by LYPLA1 and LYPLAL1 for the cysteine residues in the S0–S1 loop of the BK channel |
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acyl thioesterases LYPLA1 and LYPLAL1, but not LYPLA2, depalmitoylate BK channels |
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NMNAT2 is a substrate for cytosolic thioesterases LYPLA1 and LYPLA2 and palmitoylation/depalmitoylation dynamics are on a time scale similar to its short half-life |
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LYPLA1 and LYPLA2 were initially identified from biochemical assays as G protein depalmitoylases, yet later were shown to accept a number of S-palmitoylated protein and phospholipid substrates |
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LYPLA1-mediated depalmitoylation is a major mechanism of asymmetric cell division that maintains Notch- and Wnt-associated protein dynamics, gene expression, and cellular functions |
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Cys141 and Cys498 AAs on ACE2 are S-palmitoylated by ZDHHC3 and de-palmitoylated by LYPLA1, which is critical for the membrane-targeting of ACE2 and their extracellular vesicles (EVs) secretion to interacts with the viral spike (S) protein of the SARS-CoV-2 |