basic FUNCTION
| involved in cell proliferation |
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controlling genes regulating S phase entry and DNA synthesis |
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playing a critical role in the control of maturation cell in multiple cellular lineages (in mouse) |
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could exert a strong influence over the susceptibility to oncogenic transformation |
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acting to repress E2F-responsive genes, and having a strong capacity to inhibit transformation |
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may play an oncogenic rather than a tumor suppressor role in cells |
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in response to radiation, becomes active in the nucleus, enforces a stable G(2) arrest by target gene repression, and thus provides increased cell survival ability by minimizing propagation of cells that have irreparable DNA damage |
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induces cell death via multiple pathways in normal intestinal epithelial crypt cells but not in colon cancer cells (full mitogenic potential) |
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involved in gene repression and cell cycle exit, and also has poorly understood effects in differentiation |
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important in early stages of commitment to the lymphoid lineage |
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nuclear E2F4 may be determinant in the promotion of proliferation of human intestinal epithelial crypt cells and colorectal cancer cells |
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is required for cardiomyocyte proliferation, suggesting a function for E2F4 in mitosis |
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E2F4 and RB1 play independent cell-intrinsic roles in fetal erythropoiesis |
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involved in gene repression |
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is implicated in maintaining the G(0)/G(1) cell cycle state via transcriptional repression of genes that encode proteins required for S-phase progression |
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plays an important role in enabling osteoblast progenitors to exit the cell cycle and subsequently differentiate thereby contributing to the commitment of these cells to the bone lineage |
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can inhibit hypoxia-induced cell death in isolated ventricular cardiomyocytes |
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essential negative function of E2F4 in cardiac myocyte apoptosis |
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plays a critical role in cell cycle progression of normal and cancerous intestinal epithelial cells |
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believed to exhibit crucial control over the maintenance of a differentiated state of neurons |
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in contrast to E2F1 and E2F3, which sensitize to death, E2F4 plays a crucial protective role in neuronal death evoked by DNA damage, hypoxia, and global ischemic insult |
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likely plays a protective role in neurons from ischemic insult by forming repressive complexes that prevent prodeath factors such as Myb from being expressed |
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E2F4 and E2F5 display overlapping roles in controlling the normal development of the male reproductive system |
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MCIDAS and activated E2F4 induce multiciliated cell differentiation in primary fibroblasts |