basic FUNCTION
| required for mitotic chromosomal positioning and bipolar spindle stabilization (microtubule-based mitotic motor) |
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critical for mitotic regulation including chromosome condensation, spindle organization and cytokinesis |
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microtubule-motor molecules that possess chromatin binding activity and is important for mitotic and meiotic regulation |
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role in the DNA damage response by modulating the BRCA2/Rad51 pathway |
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plays a crucial suppressive role in tumorigenesis |
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functions as an inhibitor of gastric cancer cell proliferation |
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even in the absence of spindle bipolarity, PRC1 appears to be essential for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly, whereas KIF4A is required for limiting the length of anaphase microtubules |
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KIF22 and KIF4A contribute independently to the rapid and correct attachment of chromosomes by controlling the positioning of chromosome arms and the dynamics of microtubules, respectively |
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chromokinesins KIF22 and KIF4A promote efficient chromosome congression through the concerted generation of anti-poleward (AP) force and the regulation of spindle MT dynamics |
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mainly contributes to MT dynamics and both together with KIF22 are required for chromosome congression to the metaphase plate |
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might also have important roles in mitotic chromosome structure in vertebrate cells |
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KIF4A and condensin work in parallel to promote mitotic chromosome morphology, acting in apparent opposition to TOP2A |
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PRC1 and KIF4A, two microtubule-associated proteins required for midzone assembly, can tag microtubule plus ends |
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anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A |
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KIF4A and PPP2R5C and PPP2R5E therefore create a spatially restricted negative feedback loop counteracting AURKB in anaphase |
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chromokinesin KIF4A controls proper chromosome condensation, congression/alignment, and cytokinesis to ensure faithful genetic inheritance |