basic FUNCTION
| leads to tumor formation |
|
demethylate histone lysine and arginine residues in an oxidative reaction that requires Fe(II) and alpha-ketoglutarate as cofactors |
|
and promotes both transcriptional activation of androgen receptor target genes and proliferation of prostate cancer cells |
|
playing an important role in the development and/or progression of various type of cancers |
|
acting as a histone trimethyl demethylase |
|
histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis |
|
acts as a positive regulator for NANOG, which encodes for a key transcription factor for self-renewal in embryonic stem cells |
|
generates different methylated states at the same lysine residue provides a mechanism for fine-tuning histone methylation |
|
histone demethylase with a Jumonji C domain that catalyzes lysine (K) demethylation of histones, specifically histone H3 at lysine 9 (H3K9) and lysine 36 (H3K36) |
|
involved in maintaining gene expression programs that are important for self-renewal and differentiation in embryonic stem (ES) cells |
|
atalytic Jumonji C 2 domain catalyzes lysine (K) demethylation of histones |
|
KDM4A, KDM4B, KDM4C, catalyze demethylation of tri- and di-methylated forms of both histone H3 lysine 9 (H3K9me3/me2) and lysine 36 (H3K36me3/me2) |