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FLASH GENE
Symbol WRAP73 contributors: mct - updated : 04-01-2017
HGNC name WD repeat containing, antisense to TP73
HGNC id 12759
Location 1p36.32      Physical location : -
Synonym name
  • WD repeat domain 8
  • Synonym symbol(s) FLJ20430, MGC99569, WDR8
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 19.34 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - splicing 4400 - - heart, brain, liver, prostate, skeletal muscle, pancreas, thymus 2016 26675238
    - - splicing 1640 - - brain, liver, thymus, prostate, testis, colon, small intestine 2016 26675238
    12 - 1708 51 460 - 2016 26675238
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
     tonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone   
    Connectivecartilage   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     chondrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two WD repeats
  • HOMOLOGY
    intraspecies homolog to HPRP4P
    Homologene
    FAMILY
  • WD repeat gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • inhibitor of endochondral ossification (role in regulation of ectopic ossification)
  • the conserved WRAP73-SSX2IP complex plays a critical role in controlling proper spindle length and orientation
  • satellite and centriolar component
  • WRAP73 and CEP135 have strongly overlapping functions in ciliogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WRAP73 formed a complex and partially colocalised with SSX2IP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WRAP73 interacts with the satellite proteins SSX2IP and PCM1 as well as the centriolar proximal end component CEP135
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS