basic FUNCTION
| activated in WNT signal transduction |
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putatively involved in neural and heart development |
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regulates cell proliferation, acting as a transducer molecule for developmental processes including segmentation and neuroblast specification |
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is required for LRP6 phosphorylation and aggregation after WNT treatment |
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involved in axon differentiation mediated by the PAR3-PAR6-aPKC complex |
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may play a role in the signal transduction pathway mediated by multiple Wnt genes |
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may contribute to the progression of NSCLCs |
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may be related to prostate cancer progression through the Wnt/beta-catenin pathway |
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inducing phosphorylation of MARK2 and thus regulating its membrane localization |
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DVL1, DVL2, DVL3 are core components in the correct routing and transmission of canonical and non-canonical Wnt signals, most likely by acting in large multiprotein complexes |
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with APC mediate a WNT5A-FZD2 signal to focal adhesions to regulate cell-substrate adhesions and migration |
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is a key regulator of both the canonical Wnt and the planar cell polarity (PCP) pathway |
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important determinants of Olfactory sensory neurons (OSNs) cell differentiation and axon extension |
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cytoplasmic protein which plays pivotal roles in the embryonic development |
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association of DVL1 and DVL3 with Hirschsprung disease (HSCR), it may play an important role in the pathogenesis of HSCR |
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may be an underlying participant of oxidative stress induced by selenium deficiency |
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is a central mediator of Wnt signal transduction |