Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TUFM contributors: mct - updated : 21-04-2011
HGNC name Tu translation elongation factor, mitochondrial
HGNC id 12420
Corresponding disease
OXPHOSD2 mitochondrial oxidative phosphorylation deficiency 2
Location 16p11.2      Physical location : 28.853.731 - 28.857.729
Genatlas name eukaryotic, mitochondrial translation elongation factor Tu, 49.8 kDa
Synonym name
  • P43 antigen,mitochondrial elongation factor-like protein,homolog to E coli EF-Tu
  • elongation factor Tu, mitochondrial
  • Synonym symbol(s) EF-TuMT, EFTU, P43, COXPD4
    DNA
    TYPE functioning gene
    STRUCTURE 3.99 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2089 - 455 - 1998 9545647
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Reproductivefemale systemovary  highly
    Respiratorylung   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY GTP-binding elongation factor family, EF-TU/EF-1A subfamily
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • promoting the GTP-dependent binding of aminoacyl-tRNA to the a-site of ribosomes during protein biosynthesis
  • delivers aminoacyl-tRNA to the ribosome as part of a ternary complex (TC) with GTP, as well as elongation factor G and initiation factor
  • delivers aminoacyl–transfer RNAs (tRNAs) to the ribosome (
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein complexing with TSFM (EFTu
    EFTs)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OXPHOSD2
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS