basic FUNCTION
| traffic ATPase, cellular detoxification monophosphate (nucleoside multispecific apical organic anion transporter)acting as a putative efflux pump for cAMP and cGMP in kidney proximal tubules |
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having a function in platelet mediator storage and playing a role in inhibition of platelet function by some anti-inflammatory drugs |
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important protein, significantly contributing to dendritic cells migration toward the draining lymph nodes, and therefore relevant for the initiation of an immune response and a possible target for immunotherapy |
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mediates the efflux of certain cyclic nucleotides, eicosanoids, conjugated steroids, and uric acid |
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confers resistance to nucleoside and nucleotide analogs as well as camptothecin derivatives |
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plays an important role in renal secretion of adefovir |
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responsible for the distribution of drugs and endogenous compounds in various tissues, such as the bone marrow, kidney, and brain |
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ATP-binding cassette transporter that actively effluxes endogenous and xenobiotic substrates out of cells |
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uniquely involved in retinal angiogenesis likely |
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acts as a component of the blood–brain barrier through its pump function |
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role for ABCC4 in the regulation of cAMP in cardiac myocytes and involvement of CFTR in beta-adrenergic stimulated contraction |
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functions as a nucleotide efflux transporter and thus plays a role in the regulation of intracellular cyclic nucleotide levels |
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plays potentially a key role in fibroblast migration |
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efflux transporter of cyclic nucleotides capable of regulating the intracellular cAMP/cGMP level |
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recognized as an ATP-dependent exporter of endogenous substances as well as an increasing variety of anionic chemotherapeutics |
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independent regulator of cyclic AMP (cAMP) levels particularly in vascular smooth muscle cells and in hematopoietic cells |
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both TPMT and ABCC4 influence mercaptopurine disposition and toxicity |