Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SRGN contributors: mct - updated : 20-08-2011
HGNC name serglycin
HGNC id 9361
Location 10q22.1      Physical location : 70.847.827 - 70.864.565
Synonym name
  • hematopoetic proteoglycan core protein
  • platelet proteoglycan protein core
  • proteoglycan 1, secretory granule
  • proteoglycan protein core for mast cell secretory granule
  • secretory granule proteoglycan core peptide
  • Synonym symbol(s) PPG , PRG, SERGLYCIN, PGSG, FLJ12930, PRG1, MGC9289
    DNA
    TYPE functioning gene
    STRUCTURE 16.74 kb     3 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1270 17 158 - 2011 21075844
    EXPRESSION
    Rna function in endothelial cells and smooth muscle cells
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunelymph node   highly
    Respiratorylung   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectiveadipose    Homo sapiens
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiensAdult
    Lymphoid/Immunenatural killer Homo sapiensAdult
    Lymphoid/ImmuneT cell Homo sapiensAdult
    not specificadipocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 18 AA glycosaminoglycan-attachment region
  • HOMOLOGY
    Homologene
    FAMILY
  • serglycin family
  • CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    text core of secretory granule
    basic FUNCTION
  • may be acting as a mediator of granule-mediated apoptosis
  • hematopoietic cell granule proteoglycan, which may be important for neutralizing hydrolytic enzymes
  • may be involved in the retention of the proteases after their entry into secretory vesicles
  • important role in secretory processes in human monocytes
  • hematopoietic cell secretory granule proteoglycan, crucial for storage of specific secretory proteins in mast cells, neutrophils, and cytotoxic T lymphocytes
  • serglycin proteoglycan is a novel player in mast cell apoptosis
  • major proteoglycan in human endothelial cells, mainly secreted to the apical medium and implicated in chemokine secretion
  • potential role for serglycin in regulating proinflammatory activities of endothelial cells, possibly by affecting the storage and/or secretion of chemokines
  • adipocytokine highly expressed in epicardial adipose tissue (EAT)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by EBV
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in highly metastatic cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serves as an independent prognostic indicator of metastasis-free survival and disease-free survival in nasopharyngeal carcinoma patients
  • Therapy target
    ANIMAL & CELL MODELS
  • SG-/- murine platelet function deficiencies are related to inadequate packaging and secretion of selected alpha-granule proteins and reduced secretion of dense granule contents critical for platelet activation (