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FLASH GENE
Symbol PFKP contributors: mct - updated : 04-07-2014
HGNC name phosphofructokinase, platelet
HGNC id 8878
Location 10p15.2      Physical location : 3.109.751 - 3.178.995
Synonym symbol(s) PFKF, RP11-298E9.2, FLJ40226, PFK-C
EC.number 2.7.1.11
DNA
TYPE functioning gene
STRUCTURE 69.29 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure
  • a stretch of eight adjacent putative transcription factor binding sites, seven of which are Sp-family specific sites, and an NF-Y binding site
  • KLF4 binds to PFKP promoter and transactivates PFKP expression (proximal region of the PFKP promoter is a highly GC-rich region, where multiple putative KLF-binding regions exist)
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 2657 - 784 - 2005 15716112
    24 - 2781 - 776 - 2005 15716112
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Urinarykidney   highly
    Visualeye   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY phosphofructokinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • key enzyme for the regulation of glycolysis in the brain
  • glycolytic efficiency, which is important for the survival of cancer cells, depends primarily on the preferential expression of PFKL over the PFKM and PFKP isoforms
  • plays a critical role in cell proliferation in breast cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZBTB7A directly binds to the promoter and represses the transcription of critical glycolytic genes, including SLC2A3, PFKP, and PKM
  • cell & other
    REGULATION
    induced by by KLF4, playing a critical role in regulating the glycolytic metabolism of breast cancer cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS