Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | SPTB | contributors: - updated : 10-04-2007 |
HGNC name | spectrin, beta, erythrocytic (includes spherocytosis, clinical type I) |
HGNC id | 11274 |
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Corresponding disease |
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Location | 14q22-q23.2 Physical location : 65.213.001 - 65.289.866 | ||||
Synonym symbol(s) | SPCB, HSpTB1 |
DNA |
TYPE | functioning gene |
STRUCTURE | 76.00 kb 35 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
mono polymer | heteromer , dimer , tetramer , polymer |
HOMOLOGY |
interspecies | ortholog to murine Spnb1 |
Homologene |
FAMILY | spectrin family |
CATEGORY | structural protein |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,cytoskeleton |
basic FUNCTION | playing a role in the maintenance of the biconcave shape of erythrocytes, in the regulation of plasma membrane |
components and in the maintenance of the lipid asymmetry of the plasma membrane |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | |
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INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | SPH2 , EL3 |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |