SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,mitochondria,matrix
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,cytoskeleton,microtubule
|
text
| localized to mitochondrial matrix and inner membrane |
basic FUNCTION
| serine hydroxy-methyltransferase, pyridoxal dependent |
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catalyzing 5-10 methylene THF synthesis, "one-carbone" metabolism |
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putative regulator of cell growth and proliferation |
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involved in interconversion of serine and glycine |
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low activity of SHMT1 and SHMT2 in the placenta suggesting that, unlike in the sheep, placental conversion of serine to glycine is not a major source of fetal glycine |
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SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis |
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catalyzes the transfer of a beta-carbon from serine to tetrahydrofolate to form glycine and 5,10-methylene-tetrahydrofolate |