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FLASH GENE
Symbol ALDOA contributors: mct - updated : 21-11-2019
HGNC name aldolase A, fructose-bisphosphate
HGNC id 414
Corresponding disease
ALDOA hemolytic anemia with aldolase deficiency
Location 16p11.2      Physical location : 30.064.490 - 30.081.734
Synonym name
  • fructose-1,6-bisphosphate triosephosphate-lyase
  • muscle-type aldolase
  • lung cancer antigen NY-LU-1
  • Synonym symbol(s) ALDA, MGC10942, MGC17716, MGC17767, GSD12, HEL-S-87p
    EC.number 4.1.2.13
    DNA
    TYPE functioning gene
    STRUCTURE 7.93 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2353 39.3 364 - 2018 29992789
    9 - 3279 39.3 364 - 2018 29992789
    9 - 1569 39.3 364 - 2018 29992789
    9 - 1630 39.3 364 - 2018 29992789
    10 - 3433 - 418 - 2018 29992789
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    cell cycle     cell cycle, M
    Text liver, kidney, small intestine
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Aldoa
    intraspecies paralog to ALDOC
    Homologene
    FAMILY class I fructose-bisphosphate aldolase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    basic FUNCTION
  • reversibly cleaving FI-P and FBP to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
  • glycolytic enzyme which may localize both in nuclei and cytoplasm of cells
  • is a factor involved in the regulation of cells proliferation
  • functions as an oncogene in the highly metastatic pancreatic cancer
  • promotes epithelial-mesenchymal transition and tumorigenesis
  • contributed to activation of the EGFR/MAPK pathway, thus promoting cyclin D1 expression and enhancing proliferation and G1/S transition in non-small cell lung cancer
  • might play an important function in bladder cancer and its action may be though CDH1-EGFR signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , energetic
    signaling
  • glycolysis
  • fructose metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • control of ALDOA and VDAC2 levels by iron status of the cell
  • role of ALDOA in pancreatic cancer might attribute to its regulation of MYC, HIF1A and NFE2L2 (Nuclear Factor, Erythroid 2-Like 2), which were key regulators of glycolysis and antioxidant response control
  • cell & other
    REGULATION
    inhibited by interaction with ZNF224
    ASSOCIATED DISORDERS
    corresponding disease(s) ALDOA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in most cancers of lung
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    ALDOA-HIF1A axis may provide a new therapeutic target for metastatic lung cancer treatment
    ANIMAL & CELL MODELS