SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria,inner
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
text
| SLC11A2 not only exports iron from endosomes, but also serves to import the metal into the mitochondria |
basic FUNCTION
| mediating apical iron uptake into duodenal enterocyte and also transfering iron from the endosome into the cytosol via the transferrin receptor |
|
playing important roles in intestinal iron absorption, erythroid iron utilization, hepatic iron accumulation, placental iron transfer, but not needed for materno-fetal iron transfer |
|
involved in macrophage-specific membrane transport |
|
plays a central role in the regulation of Fe as well as other metals (Howitt 2009) |
|
SLC11A1, SLC11A2, are iron transporters that localize, respectively, to the early and late endosomal compartments |
|
is critical for nonheme iron import |
|
is the major transporter for iron entrance into mammalian cells and iron exit from endosomes during the transferrin cycle |
|
SLC39A14 plays more of a role than SLC11A2 in iron overload |
|
may likely play an important role in iron uptake into beta-cells of the pancreatic islets, which can be destroyed during iron overload |
|
influence of cytokines on SLC11A2 iron transporter and ferritin expression in insulin-secreting cells |
|
its deficiency negatively affects metabolism and life span of mature erythrocytes |
|
role of SLC11A2 in mediating the neuroregenerative action of iron |
|
is a major iron transporter required for iron absorption and erythropoiesis |