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FLASH GENE
Symbol HTR7 contributors: mct - updated : 31-05-2014
HGNC name 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
HGNC id 5302
Location 10q23.31      Physical location : 92.500.577 - 92.617.671
Synonym symbol(s) 5-HT7
DNA
TYPE functioning gene
STRUCTURE 117.10 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure
  • essential role of Sp factors in regulating HTR7 promoter activity (
  • MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3280 49.8 445 - 2007 17321075
    variant a isoform a
    3 splicing 3285 48.3 432 - 2007 17321075
    variant a isoform b
    - splicing - - - - 2007 17321075
    4 splicing 3378 53.6 479 minor isoform 2007 17321075
  • variant a isoform d
  • lacking exon cassette D at the exon II and III boundary
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   predominantly
    Nervousbrain    
     brainforebraincerebral cortex  
     brainlimbic systemhippocampus highly Homo sapiens
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Lymphoid    
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane segments (7TM) receptor
    HOMOLOGY
    interspecies ortholog to rattus 5HT7
    homolog to guinea pig GP2-7
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • co-localization between the HTR7 receptor and RHOBTB3 at the plasma membrane and in the endoplasmic reticulum
  • basic FUNCTION
  • 5-hydroxytryptamine (serotonin) receptor, activating adenylate cyclase
  • biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen
  • could reside in different dimeric contexts and initiate different signaling pathways, depending on the neuronal circuitry and/or brain region
  • involved in a wide variety of central nervous system (CNS) functions, namely circadian rhythm, depression, thermoregulation, obsessive-compulsive disorder (OCD), anxiety
  • regulated expression of HTR7 and GNA12-protein may represent a molecular mechanism by which serotonin specifically modulates formation of initial neuronal networks during early postnatal development
  • might play a crucial role in shaping neuronal morphology and behaviorally relevant neuronal networks, paving the way to new approaches able to modulate CNS connectivity
  • critical role in immune response and inflammation in the gut
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular , circadian
    text
  • circulation
  • circadian variation of expression
  • PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CAV1, specifically localized in cholesterol-enriched lipid rafts, appears to regulate constitutive and agonist-stimulated cell surface levels of HTR7 receptors via a clathrin-independent mechanism
  • RHOBTB3 is a new interaction partner of the HTR7 receptor, and RHOBTB3 strongly inhibits proteasomal degradation of HTR7 receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility unlikely to be associated with autistic disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunedigestive
    potential benefit of targeting HTR7 to alleviate the severity of intestinal inflammatory disorders such as inflammatory bowel disease
    ANIMAL & CELL MODELS
  • 5-HT(7)(-/-) mice had specific impairments in memory compilation required for resolving spatial tasks, which resulted in impaired allocentric spatial memory (