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FLASH GENE

Symbol

CDKN3

contributors: mct - updated : 14-04-2014

HGNC name	cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)
HGNC id	1791

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q22.2      Physical location : 54.863.672 - 54.886.932
Synonym symbol(s)	CDI1, KAP, CIP2, FLJ25787, KAP1
EC.number	3.1.3.16/ 3.1.3.48

DNA

TYPE	functioning gene
STRUCTURE	23.28 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005192 8 - 906 NP_005183 - 212 - 2013 2377519 NM_001130851 7 - 786 NP_001124323 - 172 - 2013 2377519

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       intestine small intestine       Lymphoid/Immune lymph node

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, G1, S, checkpoint

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	CDK inhibitor family
	protein-tyrosine phosphatase family

CATEGORY

enzyme , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	cyclin dependent kinases CDC2 (CDK1) and CDK2 (CDC2/CDK2) inhibitor, may be playing a role in cell cycle regulation
	has a dual function in cell cycling, and acts as an oncogene in hepatocellular carcinoma
	is essential for normal mitosis and G1/S transition
	controls mitosis through the CDK1 signaling axis

CELLULAR PROCESS	cell cycle
	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

text	negative control

PATHWAY

metabolism

signaling

a component

stable complex with CDK2

INTERACTION

DNA

RNA

small molecule

protein	dephosphorylates threonine-161 of CDK1 during mitotic exit
	binds and activates ROCK2 (RNA-mediated downregulation of CDKN3 leads to decreased ROCK2 activity and this, in turn, increases RAC1-mediated invasion)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be used as a novel tumor marker to predict the prognosis of epithelial ovarian cancer (EOC)
Therapy target
	System Type Disorder Pubmed cancer digestive liver antagonism of CDKN3 may be of interest for the treatment of hepatocellular carcinoma

ANIMAL & CELL MODELS