basic FUNCTION
| mediating estrogen action in various target organs |
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may act as a transcription factor, similar to several other members of the TRIM family |
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controlling breast cancer growth through ubiquitin-dependent proteolysis of 14-3-3-sigma |
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essential not only for DDX58 ubiquitination but also for DDX58-mediated interferon- production and antiviral activity in response to RNA virus infection |
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key player in oestrogen-mediated degradation of KLF5 |
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is an E3 ubiquitin ligase mediating oestrogen-induced ZFHX3 protein degradation |
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E3 ubiquitin ligases, TRIM25 and TRIM71 are validated as RNA-binding proteins (RBPs), revealing a potential link between RNA biology and protein-modification pathways |
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TRIM25 is a bona fide ZC3HAV1 cofactor that leads to increased ZC3HAV1 modification enhancing its translational inhibition activity |
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modulates the target RNA binding activity of ZC3HAV1 |
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protein induced by estrogen, playing critical roles in promoting endocrine-related cancers, including breast cancer, endometrial cancer, and prostate cancer |