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FLASH GENE
Symbol RAD52 contributors: mct/ - updated : 27-03-2014
HGNC name RAD52 homolog (S. cerevisiae)
HGNC id 9824
Location 12p13.33      Physical location : 1.021.254 - 1.058.863
Synonym name
  • DNA repair protein RAD52
  • recombination protein RAD52
  • rhabdomyosarcoma antigen MU-RMS-40.23
    • DNA
    TYPE functioning gene
    STRUCTURE 78.78 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D12S770 - D12S1256 - D12S2046 - D12S950 - D12S928 - D12S1867 - D12S352 - D12S994 - D12S341 - D12S94 - D12S591 - D12S1397 - D12S1913 - RAD52 - HTR1DP1 - D12S1587 - D12S972 - D12S1285 - D12S2047 - D12S939 - D12S1608 - D12S315 - (D12S2045 ,D12S1642 ) - D12S100 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2673 46.2 418 - 1999 10673031
    - - 2853 - 226 brain, testis 2005 16018971
  • also called RAD52B
  • truncated
  • negative regulation of RAD52
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthpalate  highly
    Reproductivemale systemprostate  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • self associating into seven-membered rings
  • two DNA binding sites (possible roles for the second DNA binding site in Rad52-mediated recombination reactions)
    • mono polymer heptamer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD52
    Homologene
    FAMILY
  • RAD52 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in meiotic recombination
  • plays essential roles in homology-dependent double-strand break repair
  • promoting the catalysis of DNA double strand break repair by the RAD51 recombinase
  • may be may exerting topological effects on the replication fork during replication repair
  • recombination mediator protein participates in maintenance of genomic integrity by functioning in homologous recombination (HR), homology-directed DNA repair (HDR), and rescue of collapsed replication forks
  • cooperates with OGG1 to repair oxidative DNA damage and enhances the cellular resistance to oxidative stress
  • role in the repair of oxidative DNA damage through a direct stimulation of the DNA glycosylase OGG1
  • with condensin, act antagonistically in the control of rDNA stability
  • dual role in controlling rDNA stability (under normal physiological conditions, it functions to maintain genomic stability through a controlled DSB repair mechanism outside the nucleolus but inappropriate localization to the nucleolus causes catastrophic events, such as cellular lifespan and reduced viability by stimulating extrachromosomal rDNA circle formation)
  • independent and alternative repair pathway of homologous recombination and a target for therapy in BRCA2-deficient cells
  • LIG4 and RAD52 genes play important roles in DNA repair mechanisms
    • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, recombination
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with phosphorylated BRCA1, BRCA2 and RAD51 for ATP dependent DNA repair of double strand breaks through homologous recombination
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • colocalizing with RPA1 heterotrimeric ssDNA binding protein
  • interacting with OGG1 (interaction has reciprocal functional consequences as OGG1 inhibits RAD52 catalytic activities and RAD52 stimulates OGG1 incision activity, likely increasing its turnover rate)
  • stably binds and wraps both, protein free and RPA1-coated ssDNA
  • specifically inhibiting RAD51 inhibition pathway
  • interact physically with the WRN helicase
  • involved in cellular response to DNA damage including phosphorylation of RAD52 by ABL kinase at tyrosine 104
  • RAD52 is potentially an alternative repair pathway of RAD51-mediated homologous recombination (HR)
  • chromatin PTEN is involved in DNA damage response partly through regulating RAD52 sumoylation
  • RAD52/MUS81-dependent mechanism promoting cell viability and genome integrity in checkpoint-deficient cells, and disclose the involvement of MUS81 to multiple processes after replication stress
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS