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FLASH GENE
Symbol MEP1B contributors: - updated : 29-03-2006
HGNC name meprin A, beta
HGNC id 7020
Location 18q12.2-q12.3      Physical location : 29.769.986 - 29.800.364
Synonym name
  • N-benzoyl-L-tyrosyl-p-aminobenzoic acid (PABA peptide) hydrolase, beta subunit
  • zinc metalloendopeptidase 1,beta subunit
  • EC.number 3.4.24.63
    DNA
    TYPE functioning gene
    STRUCTURE 30.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Endocrinethyroid    
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines colorectal carcinoma cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide,
  • a propeptide, a protease domain containing an astacin signature,
  • a meprin A-5 protein tyrosine phosphatase mu(MAM),
  • a meprin and TRAF homology domain(MATH),
  • an after MATH (AM) and an EGF like domains,
  • a putative transmembrane segment (TM)
  • a short cytoplasmic tail
  • conjugated GlycoP
    mono polymer homomer , heteromer , oligo
    HOMOLOGY
    Homologene
    FAMILY astacin family of zinc metalloendopeptidase
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION zinc endopeptidase hydrolysing basement membrane components such as collagen IV, nidogen-1 and fibronectin
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component associating with MEP1A
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to diabetic nephropathy
    Variant & Polymorphism SNP increasing the risk of diabetic nephropathy
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS