basic FUNCTION
| GTPase involved in endocytosis |
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involved in vesicular trafficking at the plasma membrane |
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regulatory role for RAB5A, RAB5B, RAB5C in not only the early endocytic pathway, but also the late endocytic pathway, of membrane trafficking in coordination with PI(3)K activity |
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selective association of RAB5A and RIN1 contributes to the dominance of RAB5A in EGFR trafficking, whereas RAB5B, RAB5C may have major functions unrelated to the EGFR degradation pathway |
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role of RAB5A, RAB5B, RAB5C as endosome organizer revealing the resilience mechanisms of the endocytic system |
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RAB5A, RAB5B, RAB5C are principal components of early endosome biogenesis |
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RAB5A, RAB5B, RAB5C selectively oversee the multiple signaling and trafficking events associated with the endocytic network |