basic FUNCTION
| G protein coupled receptor, playing a role in skin homeostasis and potential role in inflammatory response |
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transducing a signal by increasing the intracellular calcium ions level and stimulating chemotaxis in a pre-B cell line |
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CCR4 and CCR10 are expressed on epidermal keratinocytes and both are functional in terms of skin cytokine production and/or migration to their ligand CCL17 and CCL27, respectively |
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role in IgA antibody-secreting cell accumulation |
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important for the development of skin-specific gammadeltaT cells by regulating their migration and location |
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CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues |
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critical roles of CCR10 in regulating the intestinal IgA response and memory maintenance and could help in design of vaccines against intestinal and possibly other mucosal pathogens |
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is critical in the intestinal IgA response and memory maintenance |