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FLASH GENE
Symbol CCR10 contributors: mct - updated : 04-02-2012
HGNC name chemokine (C-C motif) receptor 10
HGNC id 4474
Location 17q21.1      Physical location : 40.831.421 - 40.833.845
Synonym name
  • chemokine CC receptor 10
  • G protein-coupled receptor 2
  • Synonym symbol(s) GPR2
    DNA
    TYPE functioning gene
    STRUCTURE 2.43 kb     2 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1244 - 362 adult testis, small intestine, fetal lung and kidney 2000 10725696
    - - - 2000 - 362 spleen thymus, lymph node, colon, heart, ovary, spinal cord 2000 10725696
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
     thymus   lowly
    Cardiovascularheart   lowly
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon lowly
    Reproductivefemale systemovary   
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connective    
    Epithelialbarrier/lining   
    Lymphoid    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    Blood/Hematopoieticleukocyte
    Cardiovascularendothelial cell
    Skin/Tegumentkeratinocyte Homo sapiens
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lung, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane segments (7TM) receptor
    HOMOLOGY
    interspecies homolog to murine Cnkbr9
    intraspecies homolog to IL8R
    Homologene
    FAMILY G protein coupled receptor family
    CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • G protein coupled receptor, playing a role in skin homeostasis and potential role in inflammatory response
  • transducing a signal by increasing the intracellular calcium ions level and stimulating chemotaxis in a pre-B cell line
  • CCR4 and CCR10 are expressed on epidermal keratinocytes and both are functional in terms of skin cytokine production and/or migration to their ligand CCL17 and CCL27, respectively
  • role in IgA antibody-secreting cell accumulation
  • important for the development of skin-specific gammadeltaT cells by regulating their migration and location
  • CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues
  • critical roles of CCR10 in regulating the intestinal IgA response and memory maintenance and could help in design of vaccines against intestinal and possibly other mucosal pathogens
  • is critical in the intestinal IgA response and memory maintenance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding SCYA28, SCYA27
  • ligand CCL27 (CCR10/CCL27)
  • cell & other
    REGULATION
    induced by TLR2 ligands that induce CCR9 and CCR10 expression by circulating B cells and increased chemotaxis to cognate chemokines CCL25 and CCL28
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ccr10-KO mice are not only devoid of the ability of rapid generation of IgA antibodies characterizing the memory response, they are also defective in the long-term maintenance of IgA production in the intestine, particularly during the IgA memory response to the bacteria reinfection