protein
| interacting with ADIPOQ and PRKAB1 to protects the heart from ischemia-reperfusion injury |
|
interacting with ELAVL1(can stabilize the mRNA of PTGS2, and cytoplasmic expression of ELAVL1 is associated with increased PTGS2 expression in some cancers) |
|
negatively regulating STK17B, a serine-threonine kinase implicated in the regulation of apoptosis, suggesting a novel mechanism for the effect of PTGS2 on cancer cell survival |
|
VRK2 is an active kinase playing a role in regulation of cancer cell invasion through the NFAT pathway and PTGS2 expression |
|
PTGS2 and GDF2 may form an important regulatory loop to orchestrate the osteogenic differentiation in mesenchymal stem cells |
|
PTGS2 and and VEGFC are inducers of lymphangiogenesis and their expression levels were correlated in non-Hodgkin lymphoma |
|
apoptosis-enhancing effect of FAU-BCL2L14 is due in part to down-regulation of PTGS2 activation in macrophages |
|
MAT2A interacts with histone methyltransferase SETDB1 and inhibits PTGS2 gene expression |
|
RXRA suppresses PGE2 production through inhibiting NFKB activity and PTGS2 expression |
|
CAV1 may be a cofactor in the interaction of DERL1 and PTGS2 and may facilitate DERL1- and VCP complex-mediated PTGS2 ubiquitination, retrotranslocation, and degradation |
|
AREG, BTC, and EREG induced prostaglandin E2 (PGE2) production by upregulating PTGS2 expression through ERK1/2 signaling in granulosa cells |
|
role for ADRB1 in the downregulation of PTGS2 |
|
PTH can stimulate a novel negative feedback of its anabolic actions by stimulating TNFSF1l and PTGS2 expression |
|
CPSF4 bind to PTGS2 promoter sequences directly and activate the transcription of PTGS2 |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in squamous cell carcinoma of the head and neck, in retinoblastoma, and in cholangiocarcinoma | tumoral
|  
|  
| --over
|  
|
in lung and colon adenocarcinoma, pituitary tumors and mammary tumors, in colorectal adenomas | tumoral
|  
|  
| --over
|  
|
correlated with K-RAS mutation in colorectal adenoma in progression | constitutional
|  
|  
| --over
|  
|
in neurals cell of the myenteric plexus in active inflammatory bowel disease | constitutional
|  
|  
| --over
|  
|
in amyotrophic lateral sclerosis | tumoral
|  
|  
| --over
|  
|
in renal call carcinoma | constitutional
|  
|  
|  
| loss of function
|
in cardiomyocytes may contribute to heart failure in patients receiving nonsteroidal anti-inflammatory drugs specific for inhibition of PTGS2 | tumoral
|  
|  
| --over
|  
|
in colorectal cancer (CRC), rendering tumour cells resistant to apoptosis | constitutional
|  
|  
| --over
|  
|
in the amnion is critical for the production of prostaglandins that induce labour | tumoral
|  
|  
| --low
|  
|
in squamous cell carcinoma (SCC) (pMID: 23261444) | tumoral
|  
|  
| --over
|  
|
of CPSF4 and PTGS2 proteins predicted poor prognosis of patients with lung cancers | |