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FLASH GENE
Symbol CDC27 contributors: mct - updated : 18-12-2013
HGNC name cell division cycle 27
HGNC id 1728
Location 17q21.32      Physical location : 45.195.312 - 45.266.665
Synonym name
  • nuc2 homolog
  • anaphase-promoting complex, protein 3
  • Synonym symbol(s) HGNC1728, APC3, D17S978E, HNUC, D0S1430E, NUC2, ANAPC3, CDC27Hs
    DNA
    TYPE functioning gene
    STRUCTURE 71.36 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - SLC4A1 - D17S190 - MAPT - [D17S409 - ITGB3 ] - BTR - GIP - GNGT2 - PHB - NGFR - NME1 - qter
    Authors Ho (95)
    Text [CDC27 ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 5593 - 824 - 1995 7736578
    19 - 5611 - 830 - 1995 7736578
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrainmidbrainsubstantia nigra  
    Respiratorylung    
    Urinarykidney    
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    nine tetratricopeptide repeats (TPR )
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae CDC27
    homolog to murine Cdc27
    Homologene
    FAMILY CDC27/NUC2 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be involved in controlling the timing of mitosis
  • its phosphorylation, in response to TGFB signaling can facilitate the activation of anaphase-promoting complex (APC/cyclosome)
  • CDC27 and securin participate in control of the mitotic checkpoint and survey the mitotic spindle to maintain chromosomal integrity
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the APC/C) which is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • INTERACTION
    DNA
    RNA
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • small molecule
    protein
  • RB binding
  • CDC27 directs CCND1 to alternative degradation by APC/C
  • interaction between HSF2 and the APC/C subunit CDC27 and coactivator CDC20 is enhanced by moderate heat stress, and the degradation of HSF2 is induced during the acute phase of the heat shock response
  • MCPH1 can recognize phosphorylated CDC27 via its tandem BRCT domains, and interaction between MCPH1 and CDC27 is dependent on the phosphorylation of CDC27
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CDC27 and PTTG1 appear promising biomarkers for applications in predicting disease progression, prognostication of breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential target in anti-mitotic drug development
    ANIMAL & CELL MODELS