basic FUNCTION
| Ca2+ binding protein of the retinal rd outer segments, binding to P-rhodopsin |
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inhibiting further G protein activation of desensitized receptor-arrestin complex and sequestering it through clathrin coated pits |
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also regulator of beta-adrenergic receptor A, enhancing beta2AR receptor mediated nuclear translocation of ERK |
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specialized adaptor/scaffolding protein required for internalization and signaling of members of the G protein-coupled receptor superfamily |
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having a broad role in the trafficking of integral plasma membrane protein |
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beta-arrestin-mediated signaling regulates protein synthesis |
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involved in synaptic transmission in photoreceptor cells |
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having a role as a positive regulator in NFKB signaling pathway by connecting CARD10 to GPCRs |
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key role in mediating cellular cytoprotective functions by a 7-transmembrane receptor and define the biochemical pathways involved |
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acts as a corepressor of androgen receptor (AR) by serving as a scaffold for MDM2 leading to the AR ubiquitylation and degradation |
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is required for complement C1QA expression in macrophages and constrains factor-independent survival |
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non-visual arrestins (ARR3, ARRB2) are novel centrosomal components and regulate normal centrosome function |
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both ARRB1 and ARRB2 play a novel and shared role in inhibiting G protein-dependent ERK1/2 phosphorylation |
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ARRB1, ARRB2 are cytosolic proteins well-known to participate in G protein-coupled receptor desensitisation and signalling |
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plays a critical role in BCR-ABL–induced CML through its downstream regulation of CTNNB1 signaling |
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regulates insulin sensitivity in both skeletal muscle and liver |
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unlikely to be involved in the regulation of insulin secretion, but it is required for beta cell mass plasticity |
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ARRB1, ARRB2 are now widely accepted as endocytic and signaling adaptors for G protein-coupled receptors (GPCRs), growth factor receptors, and ion channels |
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negatively regulates TLR4-mediated inflammatory reactions |