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FLASH GENE
Symbol CCT3 contributors: mct/npt - updated : 26-03-2008
HGNC name chaperonin containing TCP1, subunit 3 (gamma)
HGNC id 1616
Location 1q22      Physical location : 156.278.751 - 156.308.206
Synonym name
  • TCP1 ring complex, molecular chaperone involved in actin and tubulin folding
  • chaperonin containing TCP1, subunit 3
  • T-complex protein 1, gamma subunit
  • TCP1 (t-complex-1) ring complex, polypeptide 5
  • Synonym symbol(s) TRIC5, CCTG, CCT-gamma, TCP-1-gamma
    DNA
    TYPE functioning gene
    STRUCTURE 29.44 kb     14 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2096 - 545 - Wong, Gregory (2006)
    14 - 2093 - 544 - Wong, Gregory (2006)
    12 - 1982 - 507 - Wong, Gregory (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text pharyngeal arch 1
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , oligo
    HOMOLOGY
    Homologene
    FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • mediating ATP-dependent monomeric protein folding
  • playing a role in the assembly of the von hippel- lindau ubiquitylation complex
  • decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex
  • eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS