protein
| interacts with the Kinesin-binding proteins, TRAK1 and TRAK2, suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules |
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MFN1 and MFN2 interact with mammalian MIRO (RHOT1/RHOT2) and Milton (TRAK1) proteins, members of the molecular complex that links mitochondria to kinesin motors |
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selective binding by TRAK1 and/or TRAK2 to different members of the kinesin transport family or to RHOT1 and RHOT2 may represent crucial regulatory points in controlling the traffic of mitochondrial cargoes in neurons |
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DISC1 associates robustly with TRAK1 which is, in turn, known to interact with the outer mitochondrial membrane proteins RHOT1/2, linking mitochondria to the kinesin motor for microtubule-based subcellular trafficking |
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DISC1 couples to the mitochondrial transport and fusion machinery via interaction with the outer mitochondrial membrane GTPase proteins RHOT1, RHOT2, the TRAK1 and TRAK2 mitochondrial trafficking adaptors, and the mitochondrial fusion proteins (mitofusins) |
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physical interaction between GBF1 and RHOT1, RHOT2, and also between the active GTP-bound form of ARF1 and RHOT1, RHOT2 ( |