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FLASH GENE
Symbol MS4A7 contributors: np/ - updated : 09-03-2007
HGNC name membrane-spanning 4-domains, subfamily A, member 7
HGNC id 13378
Location 11q12.2      Physical location : 60.145.957 - 60.163.424
Synonym name
  • CD20/FC-epsilon-RI-beta family member 4
  • four-span transmembrane protein 2
  • CD20 antigen-like 4
  • high affinity immunoglobulin epsilon receptor beta subunit
  • Synonym symbol(s) CFFM4, CD20L4, MS4A8, 4SPAN2, MGC22368
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 17.47 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3024 - 240 - -
    6 - 2841 - 195 - -
    7 - 2976 - 240 - -
    6 - 2889 - 195 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Digestiveintestinelarge intestinecolon  
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/ImmuneB cell
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • transmembrane (TM) protein comprising a short intracellular domain
  • four transmembrane segments (4TM)
  • a long cytoplasmic tail, involved in intracellular signaling, lacking an immunoreceptor tyrosine-based activation motif signal
  • HOMOLOGY
    interspecies homolog to murine Ms4a2
    Homologene
    FAMILY
  • MS4A family (membrane-spanning 4-domains, subfamily A)
  • CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in mature cellular function in the monocytic lineage
  • involved in the regulation of B cell activation and proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of oligomeric cell surface complex involved in signal transduction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS