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FLASH GENE
Symbol ZAK contributors: mct/npt - updated : 02-03-2016
Corresponding disease
CNM6 centronuclear myopathy-6
Location 2q31.3      Physical location : 173.940.564 - 174.132.736
Genatlas name sterile-alpha motif and leucine zipper containing kinase AZK
Synonym name
  • MLK-like mitogen-activated protein triple kinase
  • mixed lineage kinase with a leucine zipper and a sterile alpha motif
  • cervical cancer suppressor gene 4 protein
  • MLK-related kinase
  • Synonym symbol(s) MLTK, MAPKKK, mlklak, MLK7, AZK, MLT, MRK, HCCS-4, AZKMLK7, pk
    EC.number 2.7.11.25
    DNA
    TYPE functioning gene
    STRUCTURE 192.17 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 splicing 3867 - 800 - 2001 11042189
  • MLTK alpha
  • C terminal sterile motif
  • 12 - 7194 51.3 455 - 2001 11042189
  • MLTK beta
  • C terminal region homolog to TAK1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • leucine zipper (LZ) motif
  • sterile alpha motif (SAM)
  • a kinase catalytic domain
  • mono polymer homomer , dimer , polymer
    HOMOLOGY
    Homologene
    FAMILY
  • MAPKKK family
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • disrupting actin stress fibers and shrinkage of cells
  • mitogen-activated protein kinase kinase kinase (MAP3K) that activates the stress-activated protein kinase/c-jun N-terminal kinase pathway and activates NF-kappaB
  • contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway
  • decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP1 transcription factor
  • MAPK14 and JNK pathways function downstream of ZAK during chondrogenesis
  • is a novel key regulator of chondrogenesis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text mitogen activated protein kinase kinase kinase leading to MAPK cascade
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin filaments
  • activating ERK, JNK/SAPK, p38 and ERK5 pathways
  • plays an essential role in the onset of chondrogenesis through triggering the induction of SOX6 expression by SOX9
  • cell & other
    REGULATION
    activated by osmotic shock
    ASSOCIATED DISORDERS
    corresponding disease(s) CNM6
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    ZAK activity inhibition may be a good strategy to prevent the cardiac fibrosis progression
    ANIMAL & CELL MODELS