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FLASH GENE

Symbol

PLRG1

contributors: SGE - updated : 30-06-2009

HGNC name	pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
HGNC id	9089

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q31.3      Physical location : 155.457.662 - 155.471.523
Synonym name	pleiotropic regulator 1
Synonym symbol(s)	PRL1, MGC110980, Prp46, PRPF46

DNA

TYPE	functioning gene
STRUCTURE	13.86 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002669 15 - 1797 NP_002660 57 514 - Nemeth (1998)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Lymphoid/Immune thymus       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven WD40 domains

HOMOLOGY

interspecies	homolog to murine Plrg1 (96.3pc)
	homolog to rattus Plrg1 (96.3pc)

Homologene

FAMILY

WD-repeat PRL1/PRL2 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	in spliceosome complex

basic FUNCTION	necessary for spliceosome assembly and for pre-mRNA splicing (Ajuh 2003)
	critical nuclear regulator of p53-dependent cell cycle progression and apoptosis during embryonic development and adult tissue homeostasis (Kleinridders 2009)

CELLULAR PROCESS

nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

forms a complex with Pso4/SNEV/Prp19 and CDC5L (Kleinridders 2009)

INTERACTION

DNA

RNA

small molecule

protein	interaction between the CDC5L protein and PLRG1 in the CDC5L complex essential for pre-mRNA splicing progression
	interaction between HNRPM and the spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1) that was inhibited during the heat-shock stress response

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS