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FLASH GENE
Symbol OVGP1 contributors: mct - updated : 03-09-2007
HGNC name oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)
HGNC id 8524
Location 1p13      Physical location : 111.956.937 - 111.970.399
Synonym name
  • mucin 9 (oviductin)
  • oviduct-specific glycoprotein
  • estrogen-dependent oviduct protein
  • Synonym symbol(s) MUC9, CHIT5, EGP, OGP
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     11 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure eight half estrogen -responsive element (ERE) and an imperfect ERE site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland    
    Endocrineparathyroid   highly
    Nervousbrain    
    Reproductivefemale systemoviduct   
     female systemuterus  highly
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY chitinase protein family
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secretory granules
    basic FUNCTION
  • playing a role in the fertilization process (sperm capacitation ,sperm-zona binding and zona penetration)and/or early embryonic development
  • binds to both gametes (oocytes and spermatocytes)through its interaction with MYH9 through the non-glycosylated N-terminal conserved region of OVGP1, spanning the residues 11-137
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS