Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MYO5C contributors: mct/npt/pgu - updated : 19-04-2017
HGNC name myosin VC
HGNC id 7604
Location 15q21      Physical location : 52.484.516 - 52.587.995
Synonym name myosin 5C
Synonym symbol(s) MGC74969
DNA
TYPE functioning gene
STRUCTURE 103.45 kb     41 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
41 - 6946 202.8 1742 - 2009 19008234
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 stomach    
Reproductivefemale systembreastmammary gland  
 male systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial   specific Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a globular tail domain (GTD)
  • HOMOLOGY
    Homologene
    FAMILY
  • myosin superfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be functioning as motors for actin-dependent organelle transport
  • involved in transferrin trafficking
  • play critical roles in the proper trafficking and recycling of a large number of diverse intracellular cargoes
  • multifunctional motors recruited by a variety of Rab proteins to perform multiple tasks in a variety of distinct and overlapping recycling system
  • with other myosin 5, are important modulator of synaptic plasticity
  • having an important role in the transport and turnover of mRNA
  • role for MYO5C in melanosome biogenesis and secretion
  • MYO5A, MYO5B, and MYO5C, are involved in transport of multiple cargoes
  • motor function of MYO5C was inhibited by its globular tail domain (GTD), and this inhibition was abolished by high Ca(2+), indicating that the tail inhibition mechanism is conserved in vertebrate MYO5A, B, C
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with RAB10, based on the presence of an alternatively spliced exon sequence
  • RAB38 and its close homolog RAB32 bind to MYO5C but not to MYO5A or MYO5B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS