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FLASH GENE
Symbol CCNI contributors: mct - updated : 24-06-2016
HGNC name cyclin I
HGNC id 1595
Location 4q21.1      Physical location : 77.969.178 - 77.997.125
Synonym name cyclin ITI
Synonym symbol(s) CYC1, CYI, CYC1, CCNI1
DNA
TYPE functioning gene
STRUCTURE 28.86 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1890 - 377 - 1998 9705831
- - 1443- - 178 in testis, at increased level compared to other tissues 1998 9705831
  • first ATG Met start codon at nt 1 and has the well-conserved sequence of cyclin box
  • three amino acids mutations at nt 25, 172, 223, respectively, including one in the well-conserved sequence of cyclin box
  • may have a physiological role in spermatogenesis and/or human sperm cell function--especially in capacitation and/or acrosome reaction
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunetonsils   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY cyclin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may have a physiological role in spermatogenesis and/or human sperm cell function--especially in capacitation and/or acrosome reaction
  • protects podocytes from apoptosis, and likely this is mediated by stabilization of CDKN1A
  • activators of CDK5, CDK5R1, and CCNI are not required for normal kidney function, but, they play pivotal coordinated roles in maintaining podocyte survival during stress states in disease
  • has a role in the regulation of cell cycle progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK5 is activated by both CCNI and the noncyclin activator CDK5R1 in terminally differentiated cells such as kidney podocytes and neurons
  • interaction between Cyclin I and CDK5 was detected in cells overexpressed with both proteins
  • predominance of CCNI mediates the nuclear localization of CDK5, whereas the predominance of CDK5R1 results in a membranous localization of CDK5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS