SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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text
| sequestered in the endoplasmic reticulum (ER) in a resting state and traffic to endolysosomes upon ligand-induced stimulation |
basic FUNCTION
| can recognize nucleic acids and trigger signalling cascades that activate plasmacytoid dendritic cells to produce interferon-alpha (thus contributing to the pathogenesis of systemic lupus erythematosus) |
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pathogen recognition and activation of innate immunity |
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acting via MYD88 and TRAF6, leading to the activation of NF-KappaB signaling pathway |
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inducing TNF production in plasmacytoid dendritic cells precursor and IL12 in immature (CD11C+) myeloid cells |
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acting as the host sensor for human parechovirus 1 |
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potentially involved in modulating the recognition of CpG motifs |
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acting as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus |
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play critical roles in pathogen recognition and activation of innate immunity |
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may confer susceptibility to asthma and related atopic disorders |
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initiate immune responses to infection by recognizing microbial nucleic acid |
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implicated in the sequence-dependent detection of RNA oligonucleotides in immune cells |
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involved in sequence-specific sensing of single-stranded RNAs in macrophages |
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requirement for processing of TLR7 may represent an evolutionary strategy to ensure proper self/non-self discrimination based on nucleic acid recognition |
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recognize pathogen-derived nucleotides in intracellular compartments and respond to host-derived nucleotides as well, and they have been implicated in a variety of autoimmune diseases |
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with TLR8, activate similar signaling pathways that play different roles in dendritic cells maturation, depending on which TLR is triggered |
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with TLR9, are required for plasmacytoid dendritic cells |
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TLR7-dependent EDN1 secretion by infiltrating macrophages attempting clearance of immune complexes bound apoptotic cardiocytes may be positioned as a direct inducer of the fibroblast secretion of TGFbeta |
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exerts B-cell–intrinsic effects in promoting spontaneous germinal center (GC) and plasmablast B-cell development |
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exerts B-cell–specific effects that influence B-cell fate and development of spontaneous autoimmunity |
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innate immune sensor for microbial RNA, erroneously responds to self-derived RNA |
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essential role for TLR7-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing |
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TLR7 is likely the major TLR recognizing single-stranded RNA (ssRNA) in brains |
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TLR7 plays a central role in early immune activation during malaria infection, whereas TLR7 and TLR9 contribute combinatorially to immune responses as infection progresses |
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B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers (PID: 25252960) |
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distinct roles for TLR7 and TLR9 in the differentiation of autoreactive B cells that explain the capacity of TLR9 to limit, as well as TLR7 to promote, the clinical features of systemic erythematosus lupus |
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mediates innate immune responses to viral RNA in endocytic compartments |
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TLR7 and TLR8 on trophoblastic cells play an important role in the prevention of intrauterine HBV transmission by inhibiting HBV translocation across trophoblast |
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activation of TLR7 signaling in T cells can inhibit Th17 cell differentiation from naive T cells and IL17 production in established Th17 cells |