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FLASH GENE
Symbol SLCO4A1 contributors: mct - updated : 03-10-2019
HGNC name solute carrier organic anion transporter family, member 4A1
HGNC id 10953
Location 20q13.33      Physical location : 61.273.796 - 61.303.647
Synonym name
  • organic anion transporter 1
  • solute carrier family 21 (organic anion transporter), member 12
  • colon organic anion transporter
  • Synonym symbol(s) OATPE, SLC21A12, OATP4A1, OATPRP1, POAT
    DNA
    TYPE functioning gene
    STRUCTURE 48.66 kb     12 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2716 - 722 - 2015 25301452
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunelymph node    
     thymus    
    Reproductivemale systemprostate  highly
    Urinarykidney    
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane domains
  • N glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY SLC21A superfamily of solute carriers
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transport of 3(H)estrone-3-sulfate
  • is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen
  • plays an important role in colorectal cancer cells proliferation, migration, invasion, and carcinogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein bound predominantly to the first and third PDZ binding domains of PDZK1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    SLCO1B3, SLCO2A1, SLC33A1 and SLCO4A1 are up-regulated in pancreatic adenocarcinoma (
    tumoral     --over  
    in colorectal cancerous tissue, compared with histopathologically unchanged tissue, and promoter region was hypomethylated in analyzed tissues and CRC cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be novel biomarker for tumor progression and the development of metastasis in small cell lung cancer (SCLC) patients
  • may be a valuable marker of poor prognostic for colorectal cancer (CRC)
  • Therapy target
    ANIMAL & CELL MODELS