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FLASH GENE
Symbol ETV7 contributors: npt/ - updated : 17-05-2005
HGNC name ets variant 7
HGNC id 18160
Location 6p21      Physical location : 36.333.971 - 36.355.467
Synonym name
  • TEL2 oncogene
  • Ets transcription factor TEL-2b
  • ets variant gene 7 (TEL2 oncogene)
  • Synonym symbol(s) TELB,TEL2, TREF
    DNA
    TYPE functioning gene
    STRUCTURE 21.50 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1550 39 341 - Gu
  • lacking exons 3a, 9
  • 5' variant
  • - - 1600 - 282 very weak expression Gu
    5' variant
    - - 1410 - 260 skin,very weak expression Gu
    5' variant
    - - 1380 - 286 widely Gu
  • 5' variant
  • lacking the pointed domain
  • - - 1400 - 317 low level in heart,ovary, prostate, spleen,thymus Gu
    3' variant
    - - 1280 - 262 low level in heart,Łovary,prostate,spleen,thymus,fetal liver,bone marrow Gu
    3' variant
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text peripheral blood, liver, bone marrow
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal pointed domain
  • a ETS DNA binding domain
  • a C terminal acidic domain
  • HOMOLOGY
    Homologene
    FAMILY
  • ETS family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional regulator required for hematopoiesis in bone marrow
  • CELLULAR PROCESS nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS