Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CDKL3

contributors: mct/npt - updated : 20-12-2021

HGNC name	cyclin-dependent kinase-like 3
HGNC id	15483

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q31.1      Physical location : 133.634.115 - 133.702.765
Synonym name	rat serine/threonine kinase NKIATRE homolog
	serine-threonine protein kinase NKIAMRE
	serine/threonine protein kinase,cdc2-related kinase
Synonym symbol(s)	NKIATRE, NKIAMRE
EC.number	2.7.11.22

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	136.26 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001113575 13 splicing 2222 NP_001107047 - 592 - 2003 12927787 NKIATRE beta or variant 2 NM_016508 9 splicing 1717 NP_057592 57 455 brain, nuclear 2003 12927787 NM_001349366 9 - 1355 NP_001336295 - 312 - 2003 12927787 NM_001349365 10 - 1444 NP_001336294 - 312 - 2003 12927787 NM_001349364 10 - 1495 NP_001336293 - 312 - 2003 12927787 NM_001300853 13 - 1982 NP_001287782 - 401 - 2003 12927787 NM_001349363 11 - 1584 NP_001336292 - 418 - 2003 12927787

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Reproductive male system testis       Respiratory respiratory tract trachea       Urinary kidney         Visual eye

cell lineage	hemopoietic cell lineage
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	MAP kinase dual phosphorylation motif, Thr-Aspi-Tyr motif in kinase subdomain 8
	a Thr-X-Tyr (TXY) motif in the activation loop domain
	a nuclear localization signal (NLS)

HOMOLOGY

interspecies	homolog to Drosophila RKIALRE
	homolog to C.elegans KKIALRE

intraspecies

homolog to NKIAMRE (CDKL3)

Homologene

FAMILY

proline-directed kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	restricting cell growth or maintaining differentiation
	may have a role in regulating cell growth and/or diferentiation
	may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo stage, supporting the notion that CDKL3 inactivation contributes to non-syndromic mild mental retardation (MR)
	plays an important role in the regulation of cell growth and/or differentiation
	is a critical regulator that stimulates Osteosarcoma (OS) progression by enhancing AKT1 activation

CELLULAR PROCESS	cell life, differentiation
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	regulator of cell cycle progression
	maintenance of normal hematopoiesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

CDKL3 is a promotor for glioma, probably through the regulation of RRM2 and activation of the JNK signalling pathway

cell & other

REGULATION

activated by

by treatment of cells with phorbol 12-myristate 13-acetate

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function in mental retardation tumoral   deletion     in dysmyelopoiesis tumoral     --over   in esophageal squamous cell carcinoma ESCC) with poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	biomarker for Osteosarcoma (OS) prognosis (
Therapy target
	System Type Disorder Pubmed cancer bone   potential therapeutic target to treat AKT1 hyper-activated Osteosarcoma (OS) cancer digestive oesophagus may be as a new therapeutic target in ESCC cancer brain glioma/neuroblstoma CDKL3 as a promising therapeutic target of glioma

ANIMAL & CELL MODELS