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FLASH GENE
Symbol SLC6A16 contributors: - updated : 07-10-2004
HGNC name solute carrier family 6 (neurotransmitter transporter), member 16
HGNC id 13622
Location 19q13.1-q13.4      Physical location : 49.792.893 - 49.828.474
Synonym name sodium neurotransmitter symporter family 5
Synonym symbol(s) NTT5
DNA
TYPE functioning gene
STRUCTURE 21.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Nervousbrainbasal nucleicorpus callosum highly
 brainhindbrainmedulla oblongata highly
 spinal cord   highly
Reproductivefemale systemuterus   
 male systemtestis   
 male systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebonesubchondral  
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • twelve predicted transmembrane domain (TM12)
  • intracellular N and C terminal domains and large extracellular loops between TM3 and TM4,TM7 and TM8 domains
  • two potential extracellular N-linked glycosylation sites
  • four potential protein kinase C consensus sites
  • HOMOLOGY
    interspecies homolog to rattus Ntt4
    intraspecies homolog to NTT6
    Homologene
    FAMILY neurotransmitter symporter family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    text predominantly extracellular
    basic FUNCTION
  • terminating the action of serotonine by its high affinity sodium-dependent reuptake into presynaptic terminals
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein target of psychomotor stimulants
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS