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FLASH GENE
Symbol KIR2DL5A contributors: mct/npt - updated : 28-02-2009
HGNC name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
HGNC id 16345
Location 19q13.4      Physical location : 86.690 - 96.155
Synonym name
  • natural killer cell immunoglobulin-like inhibitory receptor
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5
  • CD158f1 antigen
  • Synonym symbol(s) CD158F, KIR2DL5, KIR2DL5.1, CD158F1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text natural killer cell receptor cluster FLNKR@
    STRUCTURE 9.46 kb     8 Exon(s)
    regulatory sequence Promoter
    alternative promoter
    Binding site   transcription factor
    text structure alternative promoters, expressed variants contain an AML1 site that is mutated in the non transcribed variants
    MAPPING cloned Y linked N status provisional
    Map see FLNKR@
    RNA
    TRANSCRIPTS type messenger
    text diversity due to alternative spliced isoforms and allelic variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - polyA site 9280 - - not expressed Vilches (2000)
    - polyA site - - 375 - Vilches (2000)
    - polyA site 10720 - - not expressed Vilches (2000)
    8 - 1596 - 375 soluble Gomez-Lozano (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/HematopoieticNK cell
    Lymphoid/Immunelymphocyte
    Muscularmyocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular Ig-like domains of the D0 and D2 type and a long cytoplasmic tail with two immunoreceptor tyrosine based inhibitory motif (ITIM)
  • a putative AML1-binding site
  • HOMOLOGY
    intraspecies homolog to KIR2DL4
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • inhibiting the activity of NK cells thus preventing cell lysis
  • displays a variegated distribution on the surface of CD56(dim) NK cells (Estefanía 2007)
  • inhibitory receptor gathering a combination of genetic, structural, and functional features unique among KIR, which suggests that KIR2DL5 plays a specialized role in innate immunity (Estefanía 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS