basic FUNCTION
| motor protein of the cochlear outer hair cells, required for electromotility of the outer hair cell and for the cochlear amplifier |
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having a role for cochlea function and hearing |
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acting as an incomplete transporter, it swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space |
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functioning as a membrane motor based on piezoelectricity and may be a a prestin-containing complex in outer hair cells |
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acting as a a membrane-based motor that powers a membrane-based motor that powers cochlear outer hair cell electromotility, enabling amplification and fine-tuning of auditory signals |
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motor protein responsible for cochlear outer hair cell (OHC) somatic electromotility |
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has two voltage-dependent conformational transition steps, both of which generate mechanical displacement (two steps having distinct electromechanical coupling efficiencies) |
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is unique in its family in that it functions as a voltage-dependent motor protein manifested by two hallmarks, nonlinear capacitance and motility |
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can act as a weak Cl(-)/HCO(3)(-) antiporter and in addition to participating in wide band cochlear sound amplification, prestin may also be involved in the slow time scale (>10 s) phenomena |
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SLC26A5 which evolved from the SLC26 anion transporter family, underlies the Outer hair cells (OHCs) voltage-dependent mechanical activity (eM) |
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outer hair cell (OHC) motor protein prestin necessary for electromotility, which drives cochlear amplification and producing exquisitely sharp frequency tuning |
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increases in an attempt to partially compensate for reduced force production because of missing |
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its unique quasi-piezoelectric mechanical activity generates fast cellular motility of cochlear outer hair cells, a key process underlying active amplification in the mammalian ear |