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FLASH GENE
Symbol CPSF2 contributors: npt/mct - updated : 19/11/2008
HGNC name cleavage and polyadenylation specific factor 2, 100kDa
HGNC id 2325
Location 14q32.12      Physical location : 92.588.328 - 92.630.543
Synonym name CPSF 100 kDa subunit
Synonym symbol(s) KIAA1367, CPSF100
DNA
TYPE like-sequence
STRUCTURE 42.25 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 5072 88 782 - 2000 11124543
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Respiratoryrespiratory tracttrachea  highly
 respiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
Homologene
FAMILY
  • metallo-beta-lactamase superfamily
  • RNA-metabolizing metallo-beta-lactamase-like family
  • CPSF2/YSH1 subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • essential for maturation process
  • 3'processing of mRNAs precursors and subsequent polyadenylation
  • CPSF3 and CPSF2 act together in the process of maturation of eukaryotic pre-messenger RNAs, similar to other members of the MBL family, RNases Z and J, which function as homodimers
  • CELLULAR PROCESS nucleotide, transcription, maturation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text polyadenyaltion
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with CPSF1,3,4,poly (A) ribonuclease (PARN) and CSTF3 (cleavage stimulation factor 3)
  • INTERACTION
    DNA
    RNA binding to the AAUAA motif of the pre mRNA, upstream the cleavage site
    small molecule other, binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS