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FLASH GENE
Symbol ZNF274 contributors: mct - updated : 18-01-2014
HGNC name zinc finger protein 274
HGNC id 13068
Location 19q13.43      Physical location : 58.694.395 - 58.724.927
Synonym name
  • KRAB zinc finger protein HFB101
  • zinc finger protein with KRAB and SCAN domains 19
  • zinc finger protein zfp2
  • Synonym symbol(s) ZKSCAN19, DKFZp686K08243, FLJ37843, HFB101, ZF2, ZSCAN51
    DNA
    TYPE functioning gene
    STRUCTURE 30.57 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2794 70.6 621 - 2000 10777669
    ZNF274a
    5 - 2589 62 548 - 2000 10777669
    ZNF274b
    8 - 2890 74.8 653 - 2000 10777669
    8 - 2905 - 611 - 2000 10777669
    ZNF274d
    7 - 2809 - 579 - 2000 10777669
    ZNF274e
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • at N terminus, two Krüppel associated box (KRAB)A domains, a KRAB domain which can bind the TRIM28 protein in a 1:3 ratio (KRAB:TRIM28) with KRAB at the center of the complex
  • a leucine rich region
  • five zinc finger motifs C2H2 type
  • one KRABA domain is missing in ZNF274b
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • transcriptional repressor playing a role in the nucleolus
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ZNF274 binding sites co-localize with SETDB1, TRIM28, and H3K9me3 at the 3prime ends of zinc finger genes
  • stimulation of the MAS1 protein should result in increased nitric oxide, potentially nitrating the ZNF274/TRIM28 complex,
  • resulting in dissociation of TRIM28 and activation of the transcription of MAS1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS