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FLASH GENE
Symbol CSNK1G1 contributors: shn - updated : 13-10-2012
HGNC name casein kinase 1, gamma 1
HGNC id 2454
Location 15q22.31      Physical location : 64.457.717 - 64.648.442
Synonym name
  • CKI-gamma 1
  • casein kinase I isoform gamma-1
  • Synonym symbol(s) CK1gamma1
    EC.number 2.7.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 190.27 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D15S993 - D15S1018 - CSNK1G1 - D15S1009 - D15S1507 - qter
    RNA
    TRANSCRIPTS type messenger
    text hCK1 gamma1S encode a polypeptide consisting of 393 amino acids predominantly present in the testis PMID:11124537
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 8163 - 422 - - 11124537
    CK1 gamma1L
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately Homo sapiens
    Digestiveintestinelarge intestinecolon moderately Homo sapiens
     intestinesmall intestine  moderately Homo sapiens
     liver   moderately Homo sapiens
     stomach   moderately Homo sapiens
    Lymphoid/Immunespleen   moderately Homo sapiens
    Nervousbrain   moderately Homo sapiens
    Reproductivefemale systemplacenta  moderately Homo sapiens
     male systemtestis  highly Homo sapiens
    Respiratorylung   moderately Homo sapiens
    Urinarykidney   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal moderately Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a kinase domain
  • a C terminal region divided into two structural domains
  • a specific proximal highly basic
  • a most terminal motif common to the L isoform and Rcsk1
  • conjugated PhosphoP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to Csnk1g1, Rattus norvegicus
    ortholog to Csnk1g1, Mus musculus
    ortholog to csnk1g1, danio rerio
    ortholog to CSNK1G1, Pan troglodytes
    Homologene
    FAMILY Ser/Thr protein kinase family, casein kinase I subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in growth and morphogenesis of eukaryotic cells
  • participating in Wnt signaling by phosphorylating LRP6 and mediating the recruitment of axin
  • is a novel component of checkpoint responses that controls the interaction of a key checkpoint effector kinase with its cognate mediator protein
  • phosphorylates the CHEK1-activating domain of Claspin
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    protein
    PHYSIOLOGICAL PROCESS
    text
  • growth and morphogenesis of eukaryotic cells
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
    cell & other
    REGULATION
    Other regulated by autophosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • depletion of CSNK1G1 from human cells by siRNA results in dramatically diminished phosphorylation of Claspin and cells display impaired activation of Chk1 and resultant checkpoint defects