protein
| myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) translocated to 4, MLLT4 |
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par-3 partitioning defective 3 homolog (C. elegans), PARD3 |
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PVR |
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cytoplasmic tails of the nectins bind the F-actin–binding protein afadin and support connections with the actin cytoskeleton similar to those observed in the cadherin and integrin systems |
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molecular interaction between PVRL1 and PVRL33 is the strongest of all possible combinations of the three nectins, which is likely to be responsible for the checkerboard-like assembly of these cells |
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NECTIN3 trans-interacts with NECTIN2 to promote lymphocyte and monocyte extravasation |
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ZNF582 acts as a tumor suppressor gene in NPC (nasopharyngeal carcinoma) by regulating the transcription and expression of adhesion molecules NECTIN3 and NRXN3 |
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both NECTIN3 and NRXN3 were identified as functional targets of ZNF582, and the restoration or abrogation of these genes reversed the tumor suppressor effect of ZNF582 in nasopharyngeal carcinoma (NPC) metastasis |